Potentials of N-(2, 4-dinitro-1-naphthyl)-p-toluenesulphonamide and 2, 4-dinitro-1-naphthol as novel charge transfer acceptors in pharmaceutical analysis of some quinolones and cephalosporins

Abstract Background Quinolones and cephalosporins are antibiotic agents with activity against Gram-positive Gram-negative bacteria. They contain chromophores amine groups which electron-rich centres capable of donating electrons to electron-deficient compounds. A survey the literature revealed that 2, 4-dinitro-1-naphthol, a nitroaromatic useful in chemical synthesis, can accept charge transfer reactions. This work investigates N -(2, 4-dinitro-1-naphthyl)- p -toluenesulphonamide 4-dinitro-1-naphthol formation complexes by accepting from selected quinolones cephalosporins. Five other nitroaromatics (i.e. 4-nitro-1-naphthylamine, 2-nitro-1-naphthol, 2,4-dinitro-1-naphthylamine, 1-nitronaphthalene 1,4-dinitronaphthalene) were screened addition aforementioned compared for formation. Spot test was used establish complex at room elevated temperatures determination done visual inspection thin layer chromatographic analysis reaction mixture. Ultraviolet visible absorption spectroscopy estimate extent complexes. Results Only solutions adducts gave instant distinct colour each drug temperature. While former deep golden yellow, latter yellow their blank reagent were, lemon greenish respectively. Visual inspections 2-nitro-1-naphthol adduct showed no change solution, even though spectra The 1,4-dinitronaphthalene Conclusion spectral shows superiority charge-transfer over screened. good acceptors these drugs, hence could be as reagents ultraviolet spectrophotometric drugs.